SI joint injection vs epidural

How is an SI joint injection different from an epidural?

Medically reviewed by

Ajith Nair, M.D., board certified in Anesthesiology, Pain Medicine, Addiction Medicine, and Integrative Medicine

Last reviewed: July 2026

An SI joint injection and an epidural target different parts of your body for different problems. An SI joint injection treats pain coming from the sacroiliac joint in your pelvis. An epidural treats pain coming from irritated nerves in your spine, often the kind that shoots down a leg.

If you feel your pain low on one side near the top of your buttock, tied to sitting or standing, that points toward the SI joint. If you feel pain running down your leg with tingling or numbness, that points more toward a nerve problem an epidural would address.

The two also reach different targets. An SI joint injection places medicine into or near the joint itself. An epidural places medicine in the space around the spinal nerves. Both use imaging for guidance and both aim to reduce inflammation, but they are solving different puzzles.

If you feel unsure which one fits your pain, that is exactly what the evaluation sorts out. Your specialist uses your description, your exam, and sometimes the response to a test injection to match the treatment to the true source.

Getting the target right matters. An epidural will not do much for pain that is actually coming from the SI joint, and an SI joint injection will not help a pinched spinal nerve. This is why an accurate diagnosis comes before either one.

If you feel like your pain has features of both, mention that. Some people have more than one source, and a clear conversation about where and how you hurt helps your specialist decide which treatment to try first and what to watch for afterward.

At Kentuckiana Pain Specialists, sacroiliac joint injections is provided under the care of Ajith Nair, M.D., at our Louisville and Radcliff, Kentucky clinics. Our phones are answered 24/7 at (502) 995-4004, and a consultation is the best way to find out what fits your situation.

This is general information, not medical advice. Whether a treatment is right for you is determined by a physician after an evaluation.