Epidural Injections for Lumbar Spinal Stenosis: A Guide

Epidural Injections for Lumbar Stenosis: What to Know

Struggling With Chronic Pain?

Led by Kentucky’s leading interventional pain specialist, Dr. Ajith Nair, our team is here to help you find lasting, personalized relief.

Table of Contents

Managing chronic pain is often about breaking the cycle of inflammation and discomfort. An injection isn’t meant to be a permanent cure, but rather a powerful tool that creates a window of opportunity for your body to heal. By significantly reducing pain, it allows you to engage more effectively in other crucial therapies, like physical therapy, that build long-term strength and stability. This is the primary role of epidural steroid injections for lumbar spinal stenosis. In this article, we’ll explain how this treatment works as part of a comprehensive strategy, helping you get the breathing room you need to make lasting progress.

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Key Takeaways

  • Injections Calm Nerve Inflammation Directly: An epidural steroid injection works by delivering powerful anti-inflammatory medication right to the source of your pain. This targeted approach reduces the swelling around compressed nerves, which is key to easing the pain, numbness, and weakness associated with spinal stenosis.
  • Pain Relief Creates a Path for Physical Therapy: The primary benefit of an injection is creating a window of significant pain relief. This allows you to engage more effectively in physical therapy, which is essential for building the core strength and stability needed for lasting results.
  • Your Results Guide Your Long-Term Plan: The duration of your pain relief is a key indicator for what comes next. Lasting relief may mean another injection is a good option down the road, while short-term results signal it’s time to discuss other advanced treatments with your specialist.

What Are Epidural Steroid Injections for Lumbar Spinal Stenosis?

If you’re dealing with persistent lower back and leg pain, you may have heard the term “lumbar spinal stenosis.” This condition is a common reason people seek help for chronic pain, and epidural steroid injections are one of the most effective non-surgical treatments available. Understanding what this condition is and how these injections work is the first step toward finding meaningful relief. This treatment focuses on reducing inflammation directly at the source, helping you regain mobility and improve your quality of life.

What is lumbar spinal stenosis?

Lumbar spinal stenosis is a condition where the spinal canal in your lower back narrows. Think of it like a pipe slowly getting smaller on the inside. This narrowing is often a natural part of aging, but it can also be caused by things like bulging discs or thickened ligaments. When the space gets too tight, it can squeeze the nerves that travel through your spine down to your legs. This pressure is what causes the tell-tale symptoms: pain, numbness, cramping, or weakness in your legs, which usually feels worse when you’re standing or walking. It’s a common source of chronic back pain that can really get in the way of your daily life.

How do epidural steroid injections work?

An epidural steroid injection is a non-surgical treatment designed to tackle this inflammation head-on. The procedure involves placing a strong anti-inflammatory medicine, a corticosteroid, directly into the epidural space of your lower back. This is the area that surrounds your spinal cord and the irritated nerve roots. By delivering the medication right where it’s needed, the steroid can effectively reduce the swelling and pressure on the nerves. The goal isn’t just to mask the pain; it’s to calm the inflammation that’s causing it, providing you with significant relief. Our team specializes in epidural steroid injections to target this specific type of pain.

How injections calm nerve inflammation

The medicine used in an epidural injection is a fluid that flows easily throughout the epidural space, allowing it to coat the inflamed nerves. Unlike a pill that has to travel through your entire body, this targeted approach delivers a concentrated dose of anti-inflammatory medication directly to the problem area. This is what makes it so effective at calming down irritated nerve roots. It’s a common misconception that injections are risky for severe stenosis, but the evidence shows that these procedures can be performed safely, even when the narrowing is significant. This makes it a valuable part of our comprehensive pain management treatments for getting you the relief you need.

What Conditions Can Epidural Steroid Injections Treat?

Epidural steroid injections are a versatile tool for managing chronic pain because they target inflammation right at the source. While they are commonly associated with lumbar spinal stenosis, their benefits extend to a range of conditions that cause nerve irritation and pain in the back, neck, and legs. If you’re dealing with persistent discomfort that radiates from your spine, an ESI might be a treatment worth discussing with your specialist. The goal is to calm the inflamed nerves, giving you the space and relief needed to heal and get back to your life.

What does lumbar spinal stenosis feel like?

Lumbar spinal stenosis is a narrowing of the spinal canal in your lower back. Think of it like a traffic bottleneck for your nerves. As we age, things like disc issues or thickened ligaments can cause this space to shrink, putting pressure on the nerves that travel through it. This pressure doesn’t always stay in your back. Often, it causes pain, numbness, cramping, or weakness that travels down into your legs, especially when you’re standing or walking. If you find that your back pain gets worse with activity and feels better when you sit or lean forward, you might be experiencing the classic signs of spinal stenosis.

What other spinal conditions can injections help?

While ESIs are highly effective for spinal stenosis, they also provide significant relief for other common spinal issues. They are a go-to treatment for the sharp, radiating pain caused by a herniated disc, which is a frequent cause of sciatica. People with degenerative disc disease or osteoarthritis in the lower back also find that these injections can calm flare-ups and improve mobility. Essentially, if your pain is rooted in nerve inflammation stemming from the spine, an epidural steroid injection is one of the pain management treatments that can help break the cycle of pain and discomfort.

When are injections the next step?

An epidural steroid injection is typically considered when more conservative treatments, like physical therapy or oral medications, haven’t provided enough relief. It’s a step toward more targeted care, but it’s also part of a bigger strategy. The effectiveness of an injection helps your doctor understand your pain and plan for the long term. If an ESI gives you significant and lasting relief, it can be repeated periodically. However, if the pain relief lasts for less than three months, it may be a sign that it’s time to discuss other options with your doctor. The goal is always to find a sustainable solution that truly works for you.

How Effective Are Epidural Steroid Injections for Spinal Stenosis?

When you’re dealing with the pain of lumbar spinal stenosis, finding effective relief is the top priority. Epidural steroid injections are a common and often successful non-surgical treatment, but it’s natural to wonder how well they work and what you can realistically expect. The goal of these injections is to reduce inflammation around the compressed nerves in your spine, which in turn can significantly decrease your pain and improve your mobility.

The effectiveness of an epidural steroid injection can vary from person to person. For many, it provides the relief needed to participate more fully in physical therapy and daily activities, creating a positive cycle of recovery. For others, the results might be more modest. Factors like the severity of your stenosis, your overall health, and how your body responds to the medication all play a part. At Kentuckiana Pain Specialists, we see these injections as a key part of a comprehensive pain management plan, designed to give you breathing room from your symptoms so you can focus on long-term solutions.

How long does the pain relief last?

It’s important to have realistic expectations about the timeline for relief. An epidural steroid injection is designed to treat the painful symptoms of spinal stenosis, not the underlying cause of the nerve compression. Because of this, the pain relief is usually temporary. You might notice your pain gets a little worse for a day or two right after the procedure before it starts to improve. Most people begin to feel positive effects within two to seven days.

This relief can last anywhere from a few weeks to several months. While some people experience longer-lasting benefits, the effects typically last less than six months. The injection gives your inflamed nerves a chance to calm down, which can provide a valuable window for you to engage in other therapies that support your spine and help you manage your back pain more effectively.

What factors influence your results?

Your individual outcome from an epidural steroid injection depends on several factors. The specifics of your condition, including how long you’ve had symptoms and the severity of the stenosis, can influence how well the treatment works. Your response to past interventions, like physical therapy or other medications, can also give us clues about what to expect. We’ll discuss your complete medical history to determine if this is the right next step for you.

The good news is that even if you have severe, multilevel spinal stenosis, studies show that injections can still be performed safely and effectively. Our approach is to look at your unique situation and create a personalized treatment plan. By considering all the factors, we can better predict how you might respond and set you up for the best possible results.

Fact vs. Fiction: Common myths about epidural injections

There are a few common misconceptions about epidural steroid injections that can cause unnecessary worry. One myth is that the injections can actually make spinal stenosis worse. The available evidence doesn’t support this; in fact, research shows that these injections can be performed safely even in people with severe stenosis. Another common belief is that injections are a permanent cure. While they can be very effective for sciatica pain and other symptoms, they are meant to provide temporary relief from inflammation.

Think of an epidural injection as a tool that helps break the cycle of pain and inflammation, allowing your body to heal and enabling you to pursue other rehabilitative treatments. It’s one of many pain management treatments we use to help you regain function and improve your quality of life.

What Happens During an Epidural Steroid Injection?

If you’re considering an epidural steroid injection, it’s completely normal to have questions about what the procedure involves. Knowing what to expect can help you feel more comfortable and confident on the day of your appointment. The good news is that this is a very common and straightforward procedure that our team performs regularly. We’ll walk you through every step, from getting ready at home to the injection itself, so you feel fully prepared.

The entire process is designed with your safety and comfort in mind. We use advanced imaging to guide the treatment, ensuring the medication is delivered precisely where it’s needed most. Our goal is to make the experience as smooth and stress-free as possible while targeting the source of your back pain effectively. Let’s break down what the procedure looks like from start to finish.

How to prepare for your procedure

A little preparation can make your procedure day go smoothly. First, we’ll need to review your current health and medications. It’s important to tell us about everything you take, including over-the-counter medicines, supplements, and especially any blood thinners. We’ll also need to know if you are or might be pregnant. Based on this information, we’ll give you specific instructions, which might include temporarily stopping certain medications.

On the day of your injection, you may be asked to avoid eating or drinking for a few hours beforehand. Because you might receive a mild sedative to help you relax, you will need to arrange for someone to drive you home afterward. You can find more general information and forms in our Patient Center to help you get ready.

A step-by-step look at the injection process

The epidural steroid injection itself is a quick procedure, typically lasting only 15 to 30 minutes. You’ll be positioned comfortably on an X-ray table, usually lying on your stomach. First, we’ll clean the skin on your back and numb the area with a local anesthetic. You might feel a small pinch, similar to any other shot.

Next, using live X-ray guidance called fluoroscopy, your doctor will carefully guide a thin needle to the epidural space surrounding the inflamed nerves. This technology acts like a GPS, ensuring precise placement. Once the needle is in the correct spot, we’ll inject the steroid medication. Many people report feeling a sense of pressure, tingling, or warmth as the medication is administered, but it shouldn’t be painful.

How we ensure the injection is precise and safe

Your safety is our top priority. We take several steps to ensure every injection is both precise and safe. Before the procedure, we review your medical history and any imaging you’ve had, like an MRI, to map out the safest path for the needle. This helps us understand your specific anatomy and avoid any potential issues.

During the injection, we use fluoroscopy (live X-ray) to watch the needle in real-time as it moves toward the target area. This allows us to place the medication exactly where it needs to go to reduce inflammation and pain. This commitment to precision-guided care is a core part of our approach, ensuring you receive the most effective treatment possible from our expert team.

What to Expect After Your Epidural Steroid Injection

Knowing what comes next can make your recovery process much smoother and less stressful. After your epidural steroid injection, your experience will likely follow a predictable path. While every person’s body responds a little differently, we can give you a general idea of what to expect in the hours, days, and weeks following your procedure.

The main goals are to rest, monitor your symptoms, and give the medication time to work. Our team at Kentuckiana Pain Specialists will provide you with detailed aftercare instructions tailored to your specific situation. Think of this as your guide to a comfortable and effective recovery, helping you get the most out of your treatment. Remember, we’re here to support you, so don’t hesitate to reach out with any questions.

Your first few hours post-procedure

Immediately after the injection, you might notice that your legs feel a bit heavy or numb. Your pain may be significantly less or even gone completely. This is a normal effect of the local anesthetic we use, and it typically wears off within a few hours. Don’t be alarmed if your original pain returns once the numbing medicine fades; this is expected. You may also have some soreness at the injection site for a day or two, which can be managed with an ice pack. Because of the anesthetic, you will need someone to drive you home and should plan to take it easy for the rest of the day.

Your recovery timeline and activity guide

Most people feel well enough to return to their normal routine and work the day after their procedure. However, we recommend avoiding any strenuous activities, like heavy lifting or intense exercise, for at least 24 to 48 hours. This gives your body time to heal and allows the medication to settle into the targeted area. Gentle movement, like walking, is encouraged. The most important thing is to listen to your body. If an activity causes discomfort, it’s best to hold off for a little while longer. We’ll give you specific guidelines to follow to ensure a safe and smooth recovery.

When you’ll feel relief and what to watch for

The steroid medication isn’t instantaneous; it needs time to reduce inflammation. You may notice your back pain starting to improve within two to seven days. It’s also common for some people to experience a temporary, mild increase in pain for a couple of days before things get better. This is a normal response as the steroid begins to work. Once the anti-inflammatory effects kick in, the relief can last anywhere from several weeks to months. Be sure to watch for any signs of infection, such as fever or increased redness and swelling at the injection site, and call our office if you have any concerns.

What Are the Benefits and Risks of Epidural Steroid Injections?

Deciding on any medical procedure means weighing the potential rewards against the risks. Epidural steroid injections are a trusted and effective tool for managing pain from lumbar spinal stenosis, but it’s important to have a clear picture of what to expect. Understanding both the benefits and the potential side effects helps you partner with your doctor to make the best choice for your health. At Kentuckiana Pain Specialists, we believe an informed patient is an empowered one, so let’s walk through what you need to know.

Our goal is always to find the path that offers you the most relief with the least risk, creating a treatment plan that fits your specific needs and helps you get back to your life.

The main benefits: less pain and better mobility

The primary goal of an epidural steroid injection is straightforward: to reduce your pain. The injection delivers a potent anti-inflammatory medication directly to the source of the problem—the inflamed and irritated nerves in your spine. By calming this inflammation, the injection can significantly decrease the pain, numbness, and weakness associated with lumbar stenosis.

This relief isn’t just about feeling better; it’s about living better. When your pain subsides, your mobility often improves. You may find it easier to walk, stand for longer periods, and participate in daily activities that had become difficult. For many, this procedure provides enough relief to fully engage in physical therapy, which strengthens the back and improves long-term outcomes. It can also be an effective way to postpone or even avoid the need for surgery.

Understanding the common side effects

After your injection, it’s normal to experience some mild, temporary side effects. Most commonly, you might feel some tenderness or see a little bruising at the injection site, similar to getting any other shot. Some people experience a temporary, brief increase in their usual pain, sometimes called a “steroid flare,” before the anti-inflammatory effects kick in. This typically resolves within a day or two.

If you have diabetes, it’s important to know that the steroid can cause a temporary rise in your blood sugar levels. We recommend monitoring your levels closely for a few days after the procedure. These common side effects are usually short-lived and are a normal part of the healing process as the medication begins to work on your inflamed nerves.

Rare complications and when to call your doctor

While serious complications are uncommon, it’s important to be aware of them. These can include infection, bleeding, allergic reaction, or nerve damage. Our team, led by Dr. Ajith Nair, MD, minimizes these risks by using precise, image-guided techniques in a sterile environment.

You should contact our office or seek immediate medical attention if you experience any of the following after your procedure:

  • A severe headache that feels worse when you’re sitting up and better when you lie down.
  • A fever, chills, or other signs of infection.
  • New or worsening weakness or numbness in your legs.
  • Loss of control over your bladder or bowels.

These symptoms are very rare, but they require prompt evaluation. Your safety is our top priority, and we are always here to address any concerns you have before or after your treatment.

How Do Epidural Injections Compare to Other Treatments?

When you’re dealing with the pain of lumbar spinal stenosis, it’s natural to wonder where epidural injections fit into the bigger picture. Think of your treatment plan as a series of steps, starting with the most conservative options. An epidural steroid injection is a significant step, but it’s not the first or the last. It’s a powerful, minimally invasive tool used when other methods haven’t provided the relief you need. The goal is to find the most effective, least invasive solution that gets you back to your life. Let’s look at how these injections stack up against other common approaches.

Injections vs. conservative treatments

Most pain management plans begin with conservative treatments like physical therapy, targeted exercises, and anti-inflammatory medications. These methods are foundational and can be very effective. However, sometimes the pain and inflammation are too intense for these treatments to work on their own. That’s where an epidural steroid injection comes in. It’s often considered the next logical step when simpler approaches aren’t cutting it. The primary goal of the injection isn’t just to mask the pain, but to reduce it enough so you can fully participate in and benefit from physical therapy. It creates a window of opportunity for you to strengthen your back muscles and build long-term stability.

When is it time to consider surgery?

Many people see epidural injections as a way to postpone or even avoid major surgery, and for good reason. Surgery is typically reserved as a last resort when less invasive treatments have failed to provide lasting relief. If an injection offers relief for only a short period—say, less than three months—it may be a sign that we need to explore other options. However, this doesn’t automatically mean surgery is next. There are other advanced procedures, like radiofrequency ablation or spinal cord stimulation, that can be highly effective. We always aim to exhaust all appropriate minimally invasive options before considering a surgical referral.

How injections work with physical therapy and lifestyle changes

An epidural steroid injection is a team player in your recovery plan. It’s not meant to be a standalone fix. The steroid medication works directly on the inflamed nerves in your spine, reducing the swelling and pressure that cause your pain. This targeted relief is what allows you to move more freely and comfortably. This is your chance to make real progress with physical therapy, which is crucial for strengthening the core and back muscles that support your spine. By pairing the injection with a dedicated physical therapy program and healthy lifestyle habits, you’re not just getting temporary relief—you’re building a stronger foundation for lasting back pain management.

Are Epidural Steroid Injections Right for You?

Deciding on any medical procedure, even a minimally invasive one, is a significant choice. Epidural steroid injections are a well-established treatment for certain types of chronic pain, but they aren’t the right fit for everyone. The best way to know for sure is through a thorough consultation with a pain specialist who can review your medical history, imaging results, and symptoms.

Your unique situation is the most important factor. Together, we can look at your specific pain patterns, what you’ve tried in the past, and your goals for the future. This collaborative approach helps us determine if an epidural steroid injection is the most logical and effective next step in your pain management plan.

Who is a good candidate for this procedure?

Generally, you might be a good candidate for an epidural steroid injection if your pain stems from irritated or compressed spinal nerves. This is common with conditions like lumbar spinal stenosis, herniated discs, degenerative disc disease, or sciatica. If you experience radiating pain that travels from your lower back down your leg, or from your neck into your arm, it’s a strong sign that nerve inflammation is the culprit. These injections are designed to target that inflammation directly at the source, offering relief where oral medications may have fallen short. The goal is to reduce your pain enough to improve your mobility and allow you to participate more fully in physical therapy or daily activities.

Health factors to discuss with your doctor

Open communication is key to a safe and successful procedure. During your consultation, it’s essential to give your doctor a complete picture of your health. Be sure to mention if you are or could be pregnant, have any active infections, or have uncontrolled diabetes, as these factors can influence the treatment plan. You should also provide a full list of all medications, herbs, and supplements you take, paying special attention to blood thinners like warfarin or Plavix. We also want to hear how your back pain or stenosis affects your daily life—from your mobility and mood to your ability to do simple tasks. This information helps us tailor your care precisely to your needs.

A note on safety, even with severe stenosis

It’s natural to worry that your condition might be “too severe” for certain treatments. However, when it comes to epidural steroid injections, that’s often not the case. In fact, available evidence suggests that these injections can be performed safely even for individuals with severe, multi-level lumbar spinal stenosis. A skilled pain specialist uses advanced imaging, like fluoroscopy (a type of live X-ray), to guide the needle to the exact location, ensuring precision and minimizing risks. This careful technique allows us to deliver medication effectively while prioritizing your safety, regardless of the severity of your condition.

How Many Epidural Injections Will You Need?

One of the most common questions we hear is about the number and frequency of epidural injections. The answer isn’t the same for everyone, as your treatment plan is tailored specifically to your condition, your pain levels, and how your body responds. The goal is always to provide the most relief with the fewest procedures necessary.

Your journey with epidural steroid injections is a collaborative process. We’ll work together to monitor your progress after the first injection to determine the best next steps. For some, one injection provides months of significant relief, making it a highly effective standalone treatment for that period. For others, a short series of injections may be needed to fully address the inflammation and achieve the desired outcome. We will always discuss the plan with you, ensuring you feel informed and comfortable with the approach before moving forward. Our team is here to guide you through every stage, adjusting the plan as needed based on your unique response.

How often can you get injections?

Because these injections contain a strong anti-inflammatory steroid, we need to be mindful of how often they are administered. As a general guideline for safety and effectiveness, most doctors limit epidural steroid injections to two or three times per year. This helps minimize any potential side effects associated with the steroid medication while still providing effective pain management. The exact timing between injections depends on how you respond to the first one. Our priority is to find a schedule that gives you sustained relief without overusing the medication, ensuring your long-term health and well-being are always at the forefront of your care plan.

When do repeat treatments make sense?

A repeat injection makes sense when the first one has provided a significant period of pain relief, allowing you to function better in your daily life. If you experience several months of reduced pain and increased mobility, another injection can help maintain that progress. However, if an injection offers relief for less than three months, it may be a sign that we should explore other treatment options. The goal is to find a solution that offers durable results. We see injections as a tool, and if that tool isn’t providing lasting benefits, we will work with you to find a more effective one.

Creating your long-term pain management plan

It’s helpful to think of an epidural steroid injection as a stepping stone rather than a final destination. The primary goal is to reduce your pain enough so you can actively participate in other therapies, like physical therapy. By calming the inflammation and pain, the injection opens a window of opportunity for you to strengthen your back and core muscles, improve flexibility, and build long-term stability. This comprehensive approach is key to managing back pain effectively. Your injection is part of a larger, personalized plan designed to help you get back to the activities you love with lasting results.

What If the Injections Don’t Provide Lasting Relief?

Epidural steroid injections can be a game-changer for many people with lumbar spinal stenosis, offering significant pain relief that allows them to get back to their lives. But what happens if that relief is short-lived? It’s a valid question and a common concern. It’s important to remember that pain management is a process, not a one-time fix. If injections don’t provide the long-term results you hoped for, it doesn’t mean you’re out of options. It simply means it’s time to work with your specialist to explore the next step in your personalized care plan.

Exploring your alternative treatment options

An epidural steroid injection is designed to calm inflammation and provide a window of relief, but it doesn’t change the underlying anatomy causing the stenosis. If your pain returns, we can look at other minimally invasive procedures that offer more durable results. Treatments like radiofrequency ablation can provide relief for much longer by targeting the specific nerves sending pain signals. For more complex cases, spinal cord stimulation might be an effective option. The goal is always to find the least invasive treatment that gives you the most significant and lasting improvement in your quality of life. We have a wide range of advanced tools to help manage your pain effectively.

Signs it’s time to try a different approach

So, how do you know when it’s time to consider something else? A key indicator is the duration of your relief. If an injection helps for less than three months, it’s a clear sign that we should discuss other strategies. You should also pay attention to how your back pain affects your daily life. Are you still unable to stand or walk for long periods? Is the pain consistently interfering with your sleep or your ability to enjoy your favorite activities? If the answer is yes, even after an injection, it’s time to have a conversation about what’s next. Your treatment should meet your goals, not just temporarily mask the symptoms.

Partnering with your specialist on what’s next

Your experience is the most important piece of the puzzle. When you come in for a follow-up, being prepared to share specific details is incredibly helpful. Think about how your pain has changed, what activities are still difficult, and how your mobility and mood have been affected. This information allows us to build a clear picture of what’s working and what isn’t. Our team, led by Dr. Ajith Nair, is here to listen and collaborate with you. Together, we can assess your progress and adjust your treatment plan. Open communication is the foundation of effective pain management, ensuring your path forward is tailored specifically to your needs and goals.

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Frequently Asked Questions

Is the injection itself painful? Most people are pleasantly surprised by how manageable the procedure is. We start by numbing the skin on your back with a local anesthetic, which feels like a quick pinch. As the main needle is guided into place, you’ll likely feel a sense of pressure, but it shouldn’t be sharply painful. Our team talks you through every step, and your comfort is our main focus throughout the short procedure.

How soon can I go back to my normal activities? You’ll need to take it easy for the rest of the day, but most people are able to return to work and their usual light activities the very next day. We do recommend holding off on any strenuous exercise or heavy lifting for a couple of days to give the medication time to work and the injection site time to heal. The most important thing is to listen to your body.

Will this injection fix the narrowing in my spine? This is a great question because it gets to the heart of what these injections do. The procedure does not change the physical narrowing of your spinal canal. Instead, its purpose is to treat the inflammation and irritation of the nerves that are being squeezed. By calming that inflammation, we can significantly reduce your pain, which in turn helps you move better and get more out of other treatments like physical therapy.

Why do I need an injection if I’m already doing physical therapy? Think of them as a team working together for your benefit. Sometimes, the pain from spinal stenosis is so intense that it’s difficult to perform physical therapy exercises correctly or consistently. The injection works to reduce that pain and inflammation, creating a valuable window of opportunity where you can fully engage in your therapy, build strength, and achieve more lasting results.

How do I know if the injection worked? Relief isn’t always immediate, so patience is key. The numbing medicine will wear off within a few hours, and it’s normal for your original pain to return or even feel slightly worse for a day or two. The steroid medication typically starts working within two to seven days. You’ll know it’s working when you notice a meaningful decrease in your pain and an improvement in your ability to stand, walk, and perform daily tasks more comfortably.